The lesser concentration of the insulina in the liver causes a reduction in the GHBP synthesis (Growth Hormone Binding Protein). This reduction in the values of the GHBP leads to a reduction in the action of the GH, the values of IGF-1 and the inibitria against-regulation of this hormone, resulting in an exaggerated secretion of GH and increase of the resistance to the insulina. (LERARIO, 2005), For the cited author anteriormene, diabetes type 1, that acomete person young, in the two first decades of life, is the form most serious of the illness. land has compatible beliefs. Diabetes mellitus type 1 corresponds 5% and 10% of the cases of diabetes. The quickly gradual form is observed in adolescent children and, but it can also occur in adults. Studies in young adults with DM1, IMC normal and good glicmico control, with clamp euglicmico-hiperinsulinmico, had shown an association enter the homostasis of the glicemia, of the SHBG (sex-hormone binding globulin) and of the SDHEA (sulphate of dehidroepiandroesterona), suggesting an interrelation it also enters these factors in the regulation of sensitivity to the insulina in the DM1. However, the results of other studies, in this direction, are not homogeneous.
Women in daily pay-menopause (age 38,8 6,5 years) with normal DM1 and IMC, but with long time of diagnosis of diabetes (23,8 9,9 years), also studied with clamp euglicmico-hiperinsulinmico and compared with a group of normal women, with the same antropomtricas characteristics, it demonstrated that the patients with DM1 had a bigger degree of resistance to the insulina, but that this was not related to the abdominal adiposity, the lipdeo profile or the values of testosterone. (LERARIO, 2005) According to Goldman and Ausiello (2005), diabetes constitutes an important cause of precocious incapacity. In the United States, one is about the main cause of the blindness in adults in the productive age, of terminal renal illness and not-traumatic amputations of members.